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Sharon Lobert is Associate Dean for Graduate Studies in the School of Nursing and a Professor in the Schools of Nursing and Medicine (Department of Biochemistry). She joined the University of Mississippi Medical Center in August of 2000. She is currently responsible for oversight of the MSN and PhD in Nursing programs. Dr. Lobert has an active basic science research program related to oncology and oncology nursing. She is past associate editor for Research Highlights in Oncology Nursing Forum and contributing editor for Toxicology in Critical Care Nurse. Dr. Lobert is a member of the scientific advisory board for Bristol Myers Squibb for vinflunine development. She has numerous national and international publications and presentations in her research area and a consistent history of extramural private and federal funding for her research program.
The long range goal of Dr. Lobert’s research program is to understand why tumors are resistant to antimitotic chemotherapy agents.
Antimitotic agents have been important in cancer chemotherapy for more than 35 years. Often tumors are resistant to antimitotic agents either initially or after repeated drug cycles. These drugs interact with tubulin, the major protein of mitotic spindles. Mitotic microtubules are dynamic, undergoing assembly and disassembly while aligning chromosomes at the metaphase plate. Antimitotics halt cell division at metaphase by altering microtubule dynamics. Dr. Lobert has three ongoing projects investigating acute lymphoblastic leukemia, breast cancer and nonsmall cell lung cancer responses to antimitotic drugs, such as paclitaxel and vincristine. These projects are carried out through collaborations with students and colleagues at UMMC, as well as other universities. The SON basic science laboratories are equipped for state-of-the-art cell culture, molecular biology, fluorescence microscopy and protein chemistry studies.
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School of Nursing, University of Mississippi Medical Center, 2500 North State Street, Copyright © 2008 The University of Mississippi Medical Center. All Rights Reserved. This page last modified on October 18, 2007 |
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