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Annette B. Wysocki is a Professor in the Schools of Nursing and Medicine (Department of Surgery, Division of Plastic Surgery). She joined the University of Mississippi Medical Center in August of 2002. Prior to this she was Director of the Wound Healing Laboratory at the National Institute of Dental and Craniofacial Research (NIDCR) at the National Institutes of Health (NIH). She was also Scientific Director of the Division of Intramural Research at the National Institute of Nursing Research (NINR), National Institutes of Health from 1997-2000. While at the NINR/NIH she created, developed and implemented the Summer Genetics Institute and was appointed to serve on many NIH committees and participated in a several key NIH initiatives. She has served on the Board of Directors of the Wound Healing Society and the Wound Healing Foundation. She has held previous academic and research appointments at New York University Medical Center, Weill-Cornell Medical College, and UT-Southwestern. She is a recognized expert in wound healing and wound healing research and has presented her research findings both nationally and internationally and consults with pharmaceutical, cosmetic, and wound healing companies.
Our laboratory is focused on understanding the biological mechanisms responsible for delayed healing in chronic wounds and on developing clinical treatments to improve wound healing outcomes in adult and aged tissue.
Our efforts have been directed at understanding how matrix metalloproteinases that are activated and overexpressed in chronic wounds degrade extracellular matrix proteins and the effects that wound fluid constituents have on cell migration and adhesion. This involves an understanding of how cell-extracellular matrix interactions can facilitate or impede wound repair. Our key findings have demonstrated that two extracelllular matrix proteins, fibronectin and vitronectin, are degraded by proteases present in the local wound environment in chronic wounds, that both serine (uPA/Plasmin) and matrix metalloproteinases (MMP-9, MMP-2) are activated and overexpressed in chronic wounds and that chronic wound fluid impairs cell spreading and adhesion. Our on-going efforts are directed at studying how cells respond when exposed to different environmental conditions that may affect cell migration and adhesion using an in vitro wound model and dermal equivalents. We have also focused some attention on bacterial populations and bacterial proteases in chronic wounds. Our clinical studies are focused on the healing of split thickness skin graft donor sites, pressure ulcers, the use of topical solutions on wounds, noise stress and wound healing, and methods to measure wound healing clinically.
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School of Nursing, University of Mississippi Medical Center, 2500 North State Street, Copyright © 2008 The University of Mississippi Medical Center. All Rights Reserved. This page last modified on April 4, 2008 |
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