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Wound Lab
Annette Wysocki, PhD, RN, FAAN
In Vitro Wound |
The research focus of our laboratory is on understanding the biological mechanisms responsible for delayed healing in chronic wounds.
Our approach is to combine the use of clinical materials, such as wound fluids and tissue, with the powerful tools used in a basic science laboratory to discover the underlying pathophysiology at work in chronic wounds.
Our key findings have demonstrated that fibronectin and vitronectin is degraded by proteases present in the local wound environment in chronic wounds and that both serine (uPA/Plasmin) and matrix metalloproteinases (MMP-9, MMP-2) are activated and overexpressed in chronic wounds.
Our on-going efforts are directed at
studying how cells respond when exposed to different environmental conditions that may affect cell migration and adhesion using an in vitro wound model and dermal equivalents.
Our collaborative efforts have been directed at projects on keloids, pressure ulcers, bacteria, bacterial proteases, topical antimicrobials and split thickness skin graft donor sites.
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